Postpartum hemoglobin module

1.0 Overview

This module exists to model hemoglobin and anemia outcomes in the postpartum period among birthing parents who survive labor and is part of the postpartum component of the simulation. Notably, postpartum hemoglobin is determined from hemoglobin at end of pregnancy (an output of the pregnancy component hemoglobin module) and whether a simulant experienced postpartum hemorrhage.

2.0 Module Diagram and Data

Follow the steps below to model the postpartum hemoglobin module. Module inputs and outputs are summarized in the tables below.

  1. Determine if simulant survived labor and progressed to the postpartum period

  2. Among surviving simulants, assign postpartum hemoglobin exposure equal to hemoglobin exposure at birth

  3. Scale postpartum hemoglobin exposure for incident cases of maternal hemorrhage according to the maternal hemorrhage risk effects document

Todo

While it appears to be the case based on the values in shared functions, confirm that there are no relevant changes in the maternal hemorrhage severity split model between GBD 2019 and GBD 2023 that will impact the maternal hemorrhage risk effects document when the GBD 2023 methods appendix is published

Module required inputs

Input

Source module

Application

Note

Hemoglobin at end of pregnancy

Hemoglobin module

Informs postpartum hemoglobin exposure

Maternal hemorrhage incidence

Maternal disorders module

Incident maternal hemorrhage cases decrease postpartum hemoglobin exposure
Module outputs

Output

Value

Dependencies

Postpartum hemoglobin

Point value

Used for V&V of maternal hemorrhage effect on postpartum hemoglobin

3.0 Assumptions and limitations

  • We assume the pregnancy-specific hemoglobin thresholds for anemia apply to the first six weeks of the postartum period

4.0 Verification and Validation Criteria

  • Effect of maternal hemorrhage on postpartum hemoglobin (postpartum hemoglobin stratified by maternal hemorrhage incidence) should be as expected

5.0 References